Publications


Clinical EEG for Anesthesia Publications

Akeju O, Hamilos AE, Song AH, Pavone KJ, Purdon PL, & Brown EN. GABAcircuit level mechanisms are associated with ether-induced unconsciousness. Clinical Neurophysiology :Official Journal of the International Federation of Clinical Neurophysiology. 2016;127(6):2472-2481.

Akeju O, Kim S-E, Vazquez R, Rhee J, Pavone KJ, Hobbs L, Purdon PL, & Brown EN. Spatiotemporal dynamics of dexmedetomidine-induced electroencephalogram oscillations. Pouratian N, ed. PLoS ONE. 2016;11(10):e0163431.

Akeju O, Song AH, Hamilos AE, Pavone KJ, Flores FJ, Brown EN, & Purdon PL. Electroencephalogram signatures of ketamine-induced unconsciousness. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 2016;127(6):2414-2422.

Pavone KJ, Akeju O, Sampson A, Ling K, Purdon PL, & Brown EN. Nitrous oxide-induced slow and delta oscillations. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 2016;127(1):556-564.

Akeju O, Pavone KJ, Thum JA, Firth P, Westover MB, Puglia M, Shank E, Brown EN, & Purdon PL. Age-dependency of sevoflurane-induced electroencephalogram dynamics in children. Hemmings HC, ed. BJA: British Journal of Anaesthesia. 2015;115(Suppl 1):i66-i76.

Cornelissen L, Kim S-E, Purdon PL, Brown EN, & Berde CB. Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants. Culham JC, ed. eLife. 2015;4:e06513.

Purdon PL, Sampson A, Pavone KJ, & Brown EN. Clinical electroencephalography for anesthesiologists part 1: background and basic signatures. Anesthesiology. 2015; 123(4): 937-60.

Purdon PL, Pavone KJ, Akeju O, Smith AC, Sampson AL, Lee J, Zhou DW, Solt K, & Brown EN. The ageing brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia. Hemmings HC, ed. BJA: British Journal of Anaesthesia. 2015;115(Suppl 1):i46-i57.

Akeju O, Westover MB, Pavone KJ, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Pierce ET, Walsh JL, Brown EN, & Purdon PL. Effects of sevoflurane and propofol on frontal electroencephalogram power and coherence. Anesthesiology. 2014;121(5):990-998.

Purdon PL, Pierce ET, Mukamel EA, Prerau MJ, Walsh JL, Wong KFK, Salazar-Gomez AF, Harrell PG, Sampson A, Cimenser A, Ching S, Kopell N, Tavares-Stoeckel CL, Habeeb K, Merhar R, & Brown EN. Electroencephalogram signatures of loss and recovery of consciousness from propofol. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(12):E1142-E1151.

Brown EN, Lydic R, & Schiff ND. General anesthesia, sleep, and coma. The New England Journal of Medicine. 2010;363(27):2638-2650.


Neuroscience Study Publications

Ishizawa Y, Ahmed OJ, Patel SR, Gale JT, Sierra-Mercado D, Brown EN, & Eskandar EN. Dynamics of propofol-induced loss of consciousness across primate neocortex. The Journal of Neuroscience. 2016;36(29):7718-7726.

Taylor NE, Van Dort CJ, Kenny JD, Pei J, Guidera JA, Lee JT, Vlasov KY, Boyden ES, Brown EN, & Solt K. Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia. Proceedings of the National Academy of Sciences of the United States of America. 2016;113(45):12826-12831.

Chemali JJ, Kenny JD, Olutola O, Taylor N, Kimchi, E, Purdon PL, Brown EN, & Solt, K. Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain. Hemmings HC, ed. BJA: British Journal of Anaesthesia. 2015;115(Suppl 1):i58-i65.

Kenny JD, Taylor NE, Brown EN, & Solt K. Dextroamphetamine (but Not Atomoxetine) Induces reanimation from general anesthesia: implications for the roles of dopamine and norepinephrine in active emergence. Vyazovskiy V, ed. PLoS ONE. 2015;10(7):e0131914.

Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Chonde D, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker J, Napadow V, Brown EN, & Purdon PL. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Culham JC, ed. eLife. 2014;3:e04499.

Akeju O, Pavone KJ, Westover MB, Sampson A, Hartnack K, Brown EN, & Purdon PL. A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Anesthesiology. 2014;121(5):978-989.

Kenny JD, Westover MB, Ching S, Brown EN, & Solt K. Propofol and sevoflurane induce distinct burst suppression patterns in rats. Frontiers in Systems Neuroscience. 2014;8:237.

Mukamel EA, Pirondini E, Babadi B, Wong KF, Pierce E, Harrell PG, Walsh J, Salazar-Gomez A, Cash S, Eskandar E, Weiner V, Brown EN, & Purdon PL. A transition in brain state during propofol-induced unconsciousness. The Journal of Neuroscience. 2014;34(3):839-845.

Solt K, Van Dort CJ, Chemali JJ, Taylor NE, Kenny JD, & Brown EN. Electrical stimulation of the ventral tegmental area induces reanimation from general anesthesia. Anesthesiology. 2014;121(2):311-319.

Lewis LD, Ching S, Weiner VS, Peterfreund RA, Eskandar EN, Cash SS, Brown EN, & Purdon PL. Local cortical dynamics of burst suppression in the anaesthetized brain. Brain. 2013;136(9):2727-2737.

Taylor NE, Chemali JJ, Brown EN, & Solt K. Activation of D1 dopamine receptors induces emergence from isoflurane general anesthesia. Anesthesiology. 2013;118(1):30-39.

Vijayan S, Ching S, Purdon PL, Brown EN, & Kopell NJ. Thalamocortical mechanisms for the anteriorization of alpha rhythms during propofol-induced unconsciousness. The Journal of Neuroscience. 2013;33(27):11070-11075.

Chemali JJ, Van Dort CJ, Brown EN, & Solt K. Active emergence from propofol general anesthesia is induced by methylphenidate. Anesthesiology. 2012;116(5):998-1005.

Lewis LD, Weiner VS, Mukamel EA, Donoghue JA, Eskandar EN, Madsen JR, Anderson WS, Hochberg LR, Cash SS, Brown EN, & Purdon PL. Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(49):E3377-E3386.

Cimenster A, Purdon PL, Pierce ET, Walsh JL, Salazar-Gomez AF, Harrell PG, Tavares-Stoeckel C, Habeeb K, & Brown EN. Tracking brain states under general anesthesia by using global coherence analysis. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(21):8832-37.

Ching S, Cimenser A, Purdon PL, Brown EN, & Kopell NJ. Thalamocortical model for a propofol-induced α-rhythm associated with loss of consciousness. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(52):22665-22670.

Purdon PL, Pierce ET, Bonmassar G, Walsh J, Harrell PG, Kwo J, Deschler D, Mullaly CM, Barlow M, Merhar R, Lamus C, Maginnis S, Skoniecki D, Sullivan M, Higgins HA, & Brown EN. Simultaneous electroencephalography and functional magnetic resonance imaging of general anesthesia. Annals of the New York Academy of Sciences. 2009; 1157:61-70.


Other Relevant Topics

Wong KFK, Smith AC, Pierce ET, Harrell G, Walsh JL, Salazar AF, Tavares CL, Purdon PL, & Brown EN. Statistical modeling of behavioral dynamics during propofol-induced loss of consciousness. Journal of Neuroscience Methods. 2014;227:65-74.

Liberman MY, Ching S, Chemali J, & Brown EN. A closed-loop anesthetic delivery system for real-time control of burst suppression. Journal of Neural Engineering. 2013;10(4):046004.

Westover MB, Shafi MM, Ching S, Chemali JJ, Purdon PL, Cash SS, & Brown EN. Real-time segmentation of burst suppression patterns in critical care EEG monitoring. Journal of Neuroscience Methods. 2013;219(1):131-141.

Ching S, Liberman MY, Chemali JJ, Westover MB, Kenny JD, Solt K, Purdon PL, & Brown EN. Real-time closed-loop control in a rodent model of medically induced coma using burst suppression. Anesthesiology. 2013 Oct;119(4):848-60.

Lamus C, Hämäläinen MS, Temereanca S, Brown EN, & Purdon PL. A spatiotemporal dynamic distributed solution to the MEG inverse problem. Neuroimage. 2012 Nov;63(2):894-909.