Patrick L. Purdon, PhD

Associate Professor of Anaesthesia at Harvard Medical School
Nathaniel M. Sims Endowed Chair in Anesthesia Innovation and Bioengineering at Massachusetts General Hospital

Patrick L. Purdon, Ph.D., is an Associate Professor of Anaesthesia at Harvard Medical School and the Nathaniel M. Sims Endowed Chair in Anesthesia Innovation and Bioengineering at Massachusetts General Hospital.  Dr. Purdon received his A.B. in Engineering Sciences from Harvard College in 1996, his M.S. in Electrical Engineering from MIT in 1998, and his Ph.D. in Biomedical Engineering from MIT in 2005.  Dr. Purdon’s research in neuroengineering encompasses the mechanisms of anesthesia, Alzheimer’s disease and brain health, anesthesia and the developing brain, neural signal processing, and the development of novel technologies for brain monitoring. He has published over 90 peer-reviewed publications, is an inventor on 16 pending patents, and is a Fellow of the American Institute for Medical and Biological Engineering.  Dr. Purdon has won numerous awards, including the prestigious National Institutes of Health Director’s New Innovator Award.

Postdoctoral Fellows

LAURA A. SANTA CRUZ MERCADO, MD

The goal of Laura’s research is to investigate the underlying mechanisms of anesthetics action on the brain and the relationship between metabolic and immune brain state, neurophysiological circuits, and anesthetic drugs. In addition, Laura is interested in understanding the pathophysiology of cognitive disorders, as it relates to anesthesia and surgery, in different at-risk populations such as elderly, Alzheimer's, MS, cancer, septic, and IBD patients.
FANGYUN TIAN, PHD

Fangyun is interested in investigating the neurophysiological mechanisms of general anesthesia and consciousness using biomedical signal processing and statistical modeling approaches.
GUSTAVO BALANZA VILLEGAS, MD

Gustavo’s goal is to help develop tools and methods that improve anesthetic management during surgery and critical care. Additionally, he is interested in characterizing opioid mechanisms to better understand and address the ongoing opioid crisis.
PROLOY DAS, PHD

Proloy's broad research interest lies in computational modeling and analysis of neural signals aiming to decipher the underlying brain dynamics using statistical signal processing and machine learning tools. One of the primary focus of his research is to develop novel computational tools to mitigate the challenges that the current neural data analysis paradigms face and make them available as open-source tools for the neuroscience community. Outside of work, Proloy enjoys cooking, exercising, and paleontology.
Rodrigo Gutiérrez, MD, PHD

Rodrigo is interested in study the anesthesia-induced brain dynamics using EEG and understand the mechanism associated with anesthesia induced unconsciousness state. Rodrigo aimed to used this information to improve health and cognitive outcomes for patients undergoing surgery. Outside the Lab and the OR, Rodrigo enjoys playing tennis and learning how to play piano.
GLADIA HOTAN, PHD

Gladia is interested in EEG source localization, state-space modeling, functional connectivity
RAN LIU, PHD

Ran is broadly interested in the application of dynamical systems modeling, machine learning, and artificial intelligence methods to problems in medicine. In particular, he wishes to investigate brain function, consciousness, and cognition, and work at the intersection of machine learning and model-based methods.

Graduate Students

AMANDA BECK, MS
MIT PhD Candidate in Electrical Engineering and Computer Science

Amanda is interested in and pursuing signal processing methods to improve analysis of neural data, investigation of neurodegeneration, and design of neuromodulation systems. Amanda is also interested in a variety of medical research fields including precision medicine and AI for pathology.
MINGJIAN (ALEX) HE
HST MEMP PhD candidate

Alex is interested in understanding, diagnosing, and preventing Alzheimer’s disease with advanced signal processing and statistical modeling tools
DAVID W ZHOU, MS
PhD candidate

David is interested in general anesthesia and disorders of consciousness.
RORY VU MATHER, MS
Harvard-MIT MD/PhD Candidate

Rory is currently interested in using signal processing methods and control theory to develop new ways of diagnosing and treating psychological illnesses and neurodegenerative diseases. His current project is trying to identify unique markers for cognitive decline in cancer patients. Outside of his work, Rory is interested in medical administration, photography, and graphic design.

Research Assistants and Lab Staff

ANDREW CHEN
Clinical Research Coordinator

Andrew is interested in the use of EEG as a way to personalize anesthetic delivery and monitor brain health non-invasively, as well as finding ways to alleviate feelings of loneliness within the elderly population. Outside of work, Andrew loves spending time with his family and dogs, playing tennis, discovering new music, and reading!
TOM STONE, MS
Clinical Research Coordinator II

Tom is a mathematician turned neuroscience researcher interested in implementing novel and modern data science techniques towards understanding brain health and dynamics.
EKENEDILICHUKWU UWANAKA
Clinical Research Coordinator

Ekene is interested in brain pathology and learning about factors that influence the integrity and stability of the nervous system. Ekene wishes to learn about ways we can monitor and improve the health of the nervous system by using translational research as a guide. Outside of work, Ekene enjoys music, trying new foods, art, and watching interesting shows/movies.
JASMINE JOHNSON
Clinical Research Coordinator II

Jasmine is interested in the use of data science to solve public health issues and address healthcare disparities. In her spare time, she loves giving fun facts about the great city of Atlanta, indoor cycling and watching basketball!
KISHORE BHARADWAJ, MS
Clinical Research Coordinator II

Kishore is interested in developing and applying biostatistical techniques to better characterize and improve upon opioid management and pain outcomes. Kishore enjoys solving and creating puzzles, making music, and the Dallas Mavericks.
RAY JIANG
Clinical Research Coordinator

Ray is interested in how higher-level cognitive functions such as intelligence and consciousness are coded in neurological signaling, development, and structure. Ray is also passionate about understanding how neurological disorders like ASD and Alzheimer’s impact such functions, and how medical care can counteract these effects. In his free time, Ray loves to pretend to train for a triathlon, as well as cook and play piano and frisbee.
JUSTIN SYDLOSKI
Clinical Research Coordinator

Justin is interested in utilizing non-invasive techniques such as EEG to monitor brain health and better personalize care for patients. Outside of work, Justin enjoys traveling, cooking, and exploring the city of Boston.
ANTHONY EDGAR
Clinical Research Coordinator

Anthony is interested in researching Alzheimers disease, and cognitive aging. One day, he hopes to become a neuropsychologist and continue his research with older populations. During his free time he loves to play guitar, listen to music, and exercise!
HALEY GIBBS
Clinical Research Coordinator

Haley is interested in further understanding data techniques associated with various neuroimaging techniques that can advance knowledge of the human brain and neurodegenerative diseases such as Alzheimer’s and Parkinson’s. She plans to continue studying neurodegenerative diseases with the intent of pursuing a career in neurology.
AKRITI PANDIT, MPH
Project Coordinator

Akriti is interested in utilizing translational research to improve healthcare delivery and address healthcare inequities. In her free time, she enjoys painting, reading, and yoga!

Alumni

EVAN CHUNG
Clinical Research Coordinator

Evan wants to use EEG-monitoring to better identify the impacts of anesthesia on post-operative recovery within the elderly population and is also interested in improving access to healthy foods in underserved populations. He also loves to snowboard, cook with his wok, and work on leathercrafts!
Sam Huang
Clinical Research Coordinator


Sam is interested in neurology, anesthesia, and all things related to the brain. He wants to help get a better understanding of the underlying mechanisms of neurodegenerative diseases such as Alzheimer's and to uncover potential treatments.
TENZIN DESEL
Clinical Research Coordinator

Tenzin is interested in learning more about the pathological mechanisms underlying neurodegenerative disease such as the Alzheimer’s disease using neuroimaging (fMRI, EEG, PET) techniques.
ANDREW MULLEN, BSC
MIT Masters Student – Department of Electrical Engineering and Computer Science

Andrew's research interests include clinical electrophysiology, systems neuroscience, and neuroscience methods development.
FENG LIU, PHD

Feng is interested in developing statistical and/or machine learning models to solve brain imaging problems using EEG/MEG recordings to better understand how our brain works.
PEGAH KAHALI, MD

Pegah is interested in understanding the electrophysiological dynamics of local and global brain states, their neurometabolic determinants and underlying neurocircuitries
TAYLOR DELP
Clinical Research Coordinator


Currently, Taylor has interest in all things medicine. He is infatuated with learning. He hopes to one day become a surgeon and provide acute medical care to those less fortunate in third world nations.
Jenny Tou
Clinical Research Coordinator


Jenny is interested in using the EEG as a window to understand the human brain, and as a tool to improve the care of neurological disorders.
CHRISTOPHER COLVIN, MHSC
Senior Clinical Engineer


Christopher has been working in the areas of instructional design and healthcare human factors within the context of both research and quality improvement processes. He has been involved in the design of eLearning courses and educational content for promoting safe and effective practices for anesthesia management, medical device usage, and IV infusion delivery.
CHRIS GILL
Clinical Research Coordinator


Chris’s research interests are focused on investigating the relationship between visual perception, memory, and attention, understanding how these cognitive functions are affected by aging and neuropsychiatric disorders, and integrating this knowledge into diagnostic and therapeutic practices.
HUGO SOULAT
Research Assistant/ Data Analyst

Hugo’s research focuses on developing statistical tools to process neural data. His models are used to analyse EEG signals from subjects (and/or patients) under general anesthesia, and aim at characterizing the relationship between different neural rhythms. In doing so, he tries to provide a quicker, more efficient and more reliable estimate of the subject unconscious/unresponsiveness state.
EMILY P. STEPHEN, PHD

Emily uses statistical modeling and source localization techniques to study brain rhythms under anesthesia.
STEVEN BRANDT
Clinical Research Coordinator

Steven is interested in understanding the relationship between brain dynamics and computations in the context of sensory perception