Collaborators: Emery Brown (MIT Picower Institute, IMES / MGH Anesthesiology), Nancy Kopell (Boston University), Sydney Cash (MGH Neurology)
How do anesthetic drugs produce states of altered consciousness? How can we measure these brain states clinically to ensure that patients are receiving the right amount of sedative or anesthetic drugs? In this project we focus on the neural circuit mechanisms of anesthesia, using a multi-scale, multimodal approach spanning human studies in volunteers and neurosurgical patients, computational modeling, and animal models. Our goals are to uncover the secrets of the unconscious and anesthetized brain, and to enable precise, personalized anesthetic care for all patients.