PUBLICATIONS

Link to PudMed List of Publications

Research Investigations

  1. Hausdorff JM, Purdon PL, Peng CK, Ladin Z, Wei JY, Goldberger AL. Fractal scaling of human gait: stability of long-range correlations in stride interval dynamics. Appl. Phy 1996;80:1448-57.
  2. Solo V, Purdon PL, Brown EN, Weisskoff RM. Regularization for functional MRI models. Proceedings of the IEEE International Conference on Image Processing (ICIP), 1998, Chicago, IL, 1:714-716.
  3. Purdon PL, Weisskoff RM. Effect of temporal autocorrelation due to physiological noise and stimulus paradigm on voxel-level false-positive rates in fMRI. Human Brain Mapping 1998;6:239-49.
  4. Solo V, Purdon PL, Brown EN, Weisskoff RM. Model comparison for functional MRI.  Proceedings of the IEEE International Conference on Image Processing (ICIP), Kobe, Japan, 1999;2:649-52.
  5. Solo V, Purdon PL, Weisskoff R, Brown EN. A signal estimation approach to functional MRI. IEEE Transactions in Medical Imaging, 2001;20:26-35.
  6. Solo V, Purdon PL, Brown EN. Spatio-temporal signal processing for multi-subject functional MRI studies. Proceedings of the IEEE Conference on Acoustics Speech and Signal Processing (ICASSP), Salt Lake City, UT 2001;6:3441-4.
  7. Purdon PL, Solo V, Weisskoff RM, Brown EN. Locally regularized spatio-temporal modeling and model comparison for functional MRI. Neuroimage, Oct;14(4):912-23.
  8. Bonmassar G, Purdon PL, Jaaskelainen IP, Chiappa K, Solo V, Brown EN, Belliveau JW. Motion and ballistocardiogram artifact removal for interleaved recording of EEG and EPs during MRI. Neuroimage, Aug; 16(4):1127-42.
  9. Napadow V, Dhond RP, Purdon PL, Kettner N, Makris N, Kwong KK, Hui KKS. Correlating Acupuncture fMRI in the Human Brainstem with Heart Rate Variability.  IEEE Eng Med Biol Soc, 2005;5:4496-9.
  10. Long CJ, Deasai NU, Hämäläinen M, Temereanca S, Purdon PL, Brown EN. A dynamic solution to the ill-conditioned magnetoencephalography (MEG) source localization problem. 3rd IEEE International Symposium on Biomedical Imaging (ISBI), 2006;2006:225-8.
  11. Angelone LM, Vasios CE, Wiggins G, Purdon PL, Bonmassar G. On the effect of resistive EEG electrodes and leads during 7 Tesla MRI: simulation and temperature measurement studies. Mag Res Imaging, 2006;24(6):801-12.
  12. Zhang WT, Mainero C, Kumar A, Wiggins CJ, Benner T, Purdon PL, Bolar DS, Kwong KK, Sorensen AG. Strategies for improving the detection of fMRI activation in trigeminal pathways with cardiac gating. Neuroimage, 2006;31(4):1506-12.
  13. Long CJ, Purdon PL, Temereanca S, Hämäläinen M, Desai NU, Brown EN. Large scale Kalman filtering solutions to the electrophysiological source localization problem—A MEG case study. IEEE Eng Med Biol Soc, 2006; 1:4532-5.
  14. Vasios CE, Angelone LM, Purdon PL, Ahveninen J, Belliveau JW, Bonmassar G. EEG/(f)MRI measurements at 7 Tesla using a new EEG cap (“InkCap”).  Neuroimage, 2006:33(4):1082-92. PMID: 17035045
  15. Lamus C, Long CJ, Hämäläinen MS, Brown EN, Purdon PL. Parameter estimation and dynamic source localization for the magnetoencephalography (MEG) inverse problem. 4th IEEE International Symposium on Biomedical Imaging (ISBI), 2007;2007:1092-5.  PMID: 20407591 PMCID: PMC2855975
  16. Purdon PL, Millan H, Fuller PL, Bonmassar G. An open-source hardware and software system for acquisition and real-time processing of electrophysiology during high field MRI. Journal of Neuroscience Methods, 2008;175(2):165-86 NIHMS77940. PMID: 18761038 PMCID: PMC2855223
  17. Purdon PL, Pierce ET, Bonmassar G, Walsh J, Harrell PG, Kwo J, Deschler D, Mullaly CM, Barlow M, Merhar R, Lamus C, Maginnis S, Skoniecki D, Sullivan M, Higgins HA, Brown EN. Simultaneous electroencephalography and functional magnetic resonance imaging of general anesthesia.  Annals of the New York Academy of Sciences, 2009;1157:61-70  PMID: 19351356 PMCID: PMC2855224
  18. Chen Z, Purdon PL, Pierce ET, Harrell G, Brown EN, Barbieri R. Assessment of baroreflex Control of heart rate during anesthesia using a point process method. IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP), 2009; 2009:333-6. NIHMS136233. PMID: 20473342 PMCID: PMC2867254
  19. Napadow V, Dhond RP, Park K, Kim J, Makris N, Kwong KK, Harris RE, Purdon PL, Kettner N, Hui Time-Variant fMRI activity in the brainstem and higher structures in response to acupuncture. Neuroimage, 2009;47(1):289-301  NIHMS106982. PMID: 19345268 PMCID: PMC2692758
  20. Chen Z, Purdon PL, Pierce ET, Harrell PG, Walsh J, Salazar AF, Tavares CL, Brown EN, Barbieri R. Linear and nonlinear quantification of respiratory sinus arrhythmia during propofol general anesthesia. IEEE Eng Med Biol Soc (EMBC), 2009; 2009:5336-9 PMC2804255. PMID: 19963899 PMCID: PMC2804255
  21. Chen Z, Purdon PL, Pierce ET, Harrell PG, Walsh J, Brown EN, Barbieri R. Dynamic assessment of Baroreflex control of heart rate during induction of propofol anesthesia using a point process method. IEEE Eng Med Biol Soc (EMBC), 333-336. PMID: 20945159 PMCID: PMC3010293
  22. Purdon PL, Lamus C, Hamalainen MS, Brown EN. A state space approach to multimodal integration of simultaneously recorded EEG and fMRI. IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP), 2010; 2010:5454–7.
  23. Chen Z, Purdon PL, Brown EN, Barbieri R. A differential autoregressive modeling approach within a point process framework for non-stationary heartbeat intervals analysis. IEEE Eng Med Biol Soc. 2010; 2010:3567-70 NIHMS PMID: 21096829 PMCID: PMC3059729
  24. Ching S, Cimenser A, Purdon PL, Brown EN, Kopell NJ. Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness. Proceedings of the National Academy of Sciences. 2010;107(52):22665-70  PMID: 21149695 PMCID: PMC3012501
  25. Chen Z, Purdon PL, Harrell PG, Pierce ET, Walsh J, Brown EN, Barbieri R. Dynamic assessment of baroreflex control of heart rate during induction of propofol anesthesia using a point process method. Ann Biomed Eng, 2011;39(1):260-76 NIHMS247748. PMID: 20945159 PMCID: PMC3010293
  26. Cimenser A, Purdon PL, Pierce ET, Walsh J. Salazar AF, Harrell PG, Tavares-Stoeckel C, Habeeb K, Brown EN. Tracking brain states under general anesthesia by using global coherence analysis. Proceedings of the National Academy of Sciences. 2011;108(21):8832-7. PMID: 21555565 PMCID: PMC3102391
  27. Long CJ, Purdon PL, Temereanca S, Desai NU, Hämäläinen MS, Brown EN. State-space solutions to the dynamic magnetoencephalography inverse problem using high performance computing. Ann Appl Stat. 2011;5(2B):1207-28. PMID: 22081780 PMCID: PMC3212953
  28. Lamus C, Hämäläinen MS, Temereanca S, Brown EN, Purdon PL. A spatiotemporal dynamic distributed solution to the MEG inverse problem. Neuroimage 2012 Nov 1;63(2):894-909. Epub 2011 Nov 30. PMID: 22155043 PMCID: PMC3432302
  29. Mukamel EA, Wong KF, Prerau MJ, Brown EN, Purdon PL. Phase-based measures of cross-frequency coupling in brain electrical dynamics under general anesthesia. Conf Proc IEEE Eng Med Biol Soc 2011;2011:1981-4. PMID: 22254722 PMCID: PMC3282123
  30. Wong KF, Smith AC, Pierce ET, Harrell PG, Walsh JL, Salazar AF, Tavares CL, Cimenser A, Prerau MJ, Mukamel EA, Sampson A, Purdon PL, Brown EN. Bayesian analysis of trinomial data in behavioral experiments and its application to human studies of general anesthesia. Conf Proc IEEE Eng Med Biol Soc 2011;2011:4705-8. PMID: 22255388 PMCID: PMC3282046
  31. Wong KF, Mukamel EA, Salazar AF, Pierce ET, Harrell PG, Walsh JL, Sampson A, Brown EN, Purdon PL. Robust time-varying multivariate coherence estimation: Application to electroencephalogram recordings during general anesthesia. Conf Proc IEEE Eng Med Biol Soc 2011;2011:4725-8. PMID: 22255393 PMCID: PMC3293406
  32. Chen Z, Citi L, Purdon PL, Brown EN, Barbieri R. Instantaneous assessment of autonomic cardiovascular control during general anesthesia. Conf Proc IEEE Eng Med Biol Soc 2011;2011:8444-7. PMID: 22256307 PMCID: PMC3299323
  33. Ching S, Purdon PL, Vijayan S, Kopell NJ, Brown EN. A neurophysiological-metabolic model for burst suppression. Proceedings of the National Academy of Sciences 2012 Feb 21;109(8):3095-100. Epub 2012 Feb 7. PMID: 22323592 PMCID: PMC3286963
  34. Chen Z, Purdon PL, Brown EN, Barbieri R. A unified point process probabilistic framework to assess heartbeat dynamics and autonomic cardiovascular control. Front Physiol 2012;3:4. Epub 2012 Feb 1. PMID: 22375120 PMCID: PMC3269663
  35. Citi L, Valenza G, Purdon PL, Brown EN, Barbieri R. Monitoring Heartbeat Nonlinear Dynamics during General Anesthesia by using the Instantaneous Dominant Lyapunov Exponent.  Conf Proc IEEE Eng Med Biol Soc 2012 Aug; 2012: 3124-3127. PMID: 23366587 
  36. Obregon G, Babadi B, Lamus C, Brown EN, Purdon PL. A Fast iterative greedy algorithm for MEG source localization.  Conf Proc IEEE Eng Med Biol Soc 2012 Aug; 2012:6748-51. PMID: 23367478 
  37. Pirondini E, Babadi B, Lamus C, Brown EN, Purdon PL. A spatially-regularized dynamic source localization algorithm for EEG. Conf Proc IEEE Eng Med Biol Soc 2012 Aug; 2012:6752-5. PMID: 23367479 
  38. Sampson A, Babadi B, Prerau MJ, Mukamel EA, Brown EN, Purdon PL. A beamforming approach to phase-amplitude modulation analysis of multi-channel EEG. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012:6731-4. PMID: 23367474 PMCID: PMC3753031
  39. Lewis LD, Weiner VS, Mukamel EA, Donoghue JA, Eskandar EN, Madsen JR, Anderson WS, Hochberg LR, Cash SS, Brown EN, Purdon PL. Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness. Proceedings of the National Academy of Sciences. 2012 Dec 4;109(49):E3377-86. doi: 10.1073/pnas.1210907109. Epub 2012 Nov 5. (Subject of PNAS Editorial; Honorable Mention in 2013 MGH Martin Prize for the best paper coming out of MGH during the previous year). PMID: 23129622 PMCID: PMC3523833
  40. Purdon PL, Pierce ET, Mukamel EA, Prerau MJ, Walsh JL, Wong KFK, Salazar-Gomez AF, Harrell PG, Sampson A, Cimenser A, Ching S, Kopell N, Tavares-Stoeckel CL, Habeeb K, Merhar R, Brown EN. Electroencephalogram signatures of loss and recovery of consciousness from propofol. Proceedings of the National Academy of Sciences, 2013 Mar 19;110(12):E1142-51.Epub Mar 4 2013. PMID: 23487781 PMCID: PMC3607036
  41. Ching S, Liberman MY, Chemali JJ, Westover MB, Kenny J, Solt K, Purdon PL, Brown EN. Real-time Closed-loop Control in a Rodent Model of Medically Induced Coma Using Burst Suppression. Anesthesiology. 2013 Jun 13. [Epub ahead of print] PMID: 23770601 PMCID: PMC3857134
  42. Vijayan S, Ching S, Purdon PL, Brown EN, Kopell NJ. Thalamocortical mechanisms for the anteriorization of α rhythms during propofol-induced unconsciousness. J Neurosci. 2013 Jul 3;33(27):11070-5. doi: 10.1523/JNEUROSCI.5670-12.2013. PMID:23825412 PMCID: PMC3718379
  43. Lewis LD, Ching S, Weiner VS, Peterfreund RA, Eskandar EN, Cash SS, Brown EN, Purdon PL. Local cortical dynamics of burst suppression in the anaesthetized brain. 2013 Sep;136(Pt 9):2727-37. doi: 10.1093/brain/awt174. Epub 2013 Jul 25. PMID:23887187 PMCID: PMC3754454
  44. Westover MB, Shafi MM, Ching S, Chemali JJ, Purdon PL, Cash SS, Brown EN. Real-time segmentation of burst suppression patterns in critical care EEG monitoring. J Neurosci Methods. 2013 Sep 30;219(1):131-41. doi: 10.1016/j.jneumeth.2013.07.003. Epub 2013 Jul 23. PMID: 23891828 PMCID: PMC3939433
  45. Chemali J, Ching S, Purdon PL, Solt K, Brown EN. Burst suppression probability algorithms: state-space methods for tracking EEG burst suppression. J Neural Eng. 2013 Oct;10(5):056017. doi: 10.1088/1741-2560/10/5/056017. Epub 2013 Sep 10. PMID: 24018288 PMCID: PMC3793904
  46. Babadi B, Obregon-Henao G, Lamus C, Hämäläinen MS, Brown EN, Purdon PL. A Subspace Pursuit-based Iterative Greedy Hierarchical solution to the neuromagnetic inverse problem. Neuroimage. 2014 Feb 15;87:427-43. doi: 10.1016/j.neuroimage.2013.09.008. Epub 2013 Sep 18. PMID: 24055554 PMCID: PMC3946905
  47. Prerau MJ, Purdon PL, Eden UT. Tracking non-stationary spectral peak structure in EEG data. Conf Proc IEEE Eng Med Biol Soc. 2013 Jul;2013:417-20. doi: 10.1109/EMBC.2013.6609525. PMID: 24109712
  48. Prerau MJ, Purdon PL. A Probabilistic Framework for Time-Frequency Detection of Burst Suppression. IEEE EMBS Conference on Neural Engineering, 609-612. 2013. PMCID: Pending
  49. Krishnaswamy P, Bonmassar G, Purdon PL, Brown EN. Reference-free harmonic regression technique to remove EEG-fMRI ballistocardiogram artifacts. Conf Proc IEEE Eng Med Biol Soc. 2013 Jul;2013:5426-9. doi: 10.1109/EMBC.2013.6610776. PMID: 24110963 PMCID: Pending
  50. Vijayan S, Ching S, Purdon PL, Brown EN, Kopell N. Biophysical modeling of alpha rhythms during halothane-induced unconsciousness. IEEE EMBS Conference on Neural Engineering, 2013 Nov; doi: 10.1109/NER.2013.6696130. PMCID: PMC4180520
  51. Ba D, Babadi B, Purdon PL, Brown EN. Convergence and Stability of Iteratively Re-weighted Least Squares Algorithms. IEEE Trans Signal Proc. 62(1): 183-195 doi: 10.1109/TSP.2013.2287685. PMCID: Pending
  52. Mukamel EA, Pirondini E, Babadi B, Wong KFK, Pierce ET, Harrell PG, Walsh JL, Salazar-Gomez AF, Cash SS, Eskandar EN, Weiner VS, Brown EN, Purdon PL. A transition in brain state during propofol induced unconsciousness. Journal of Neuroscience. 2014 Jan 15;34(3):839-45. doi: 10.1523/JNEUROSCI.5813-12.2014. PMID: 24431442 PMCID: PMC3891963
  53. Wong KF, Smith AC, Pierce ET, Harrell G, Walsh JL, Salazar AF, Tavares CL, Purdon PL, Brown EN. Statistical modeling of behavioral dynamics during propofol-induced loss of consciousness. Journal of Neuroscience Methods. 2014 Feb 14;227C:65-74. doi: 10.1016/j.jneumeth.2014.01.026. [Epub ahead of print]. PMID: 24530701. PMCID: PMC4304648
  54. Akeju O, Pavone KJ, Westover MB, Vazquez R, Michael MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Lei G, Pierce ET, Walsh JL, Brown EN, Purdon PL. A Comparison of Propofol- and Dexmedetomidine-induced Electroencephalogram Dynamics Using Spectral and Coherence Analysis. Anesthesiology 2014 Sep 3. [Epub ahead of print] PMID: 25187999 PMCID: PMC4304638: Pending NIHMSID: 619322
  55. Akeju O, Westover MB, Pavone KJ, Sampson AL, Hartnack KE, Brown EN, Purdon PL. Effects of Sevoflurane and Propofol on Frontal EEG Power and Coherence. Anesthesiology 2014 Sep 17. [Epub ahead of print] PMID: 25233374 PMCID: PMC4206606: NIHMSID: 622540
  56. Prerau MJ, Hartnack KE, Obregon-Henao G, Sampson A, Merlino M, Gannon K, Bianchi MT, Ellenbogen JM, Purdon PL. Tracking the Sleep Onset Process: An Empirical Model of Behavioral and Physiological Dynamics. PLoS Computational Biology 2014 Oct 2;10(10):e1003866. doi: 10.1371/journal.pcbi.1003866. eCollection 2014 Oct. PMID: 25275376 PMCID: PMC4183428:. (Featured article in “Hero” section of PLoS Comp Bio homepage)
  57. Ba D, Babadi B, Purdon PL, Brown EN. Neural spike train denoising by point process re-weighted iterative smoothing. Conference record / Asilomar Conference on Signals, Systems & Computers. Asilomar Conference on Signals, Systems & Computers. 2014 November 2; :763 – 768.
  58. Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown E, Purdon PL. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Elife. 2014 Nov 28;3. doi: 10.7554/eLife.04499. [Epub ahead of print] PMID: 25432022 PMCID:
  59. Ba D, Babadi B, Purdon PL, Brown EN. Robust spectrotemporal decomposition by iteratively reweighted least squares. Proceedings of the National Academy of Sciences. 2014 Dec 16;111(50):E5336-45. doi: 10.1073/pnas.1320637111. Epub 2014 Dec 2. PMID: 25468968 PMCID: PMC4273341
  60. Westover MB, Ching S, Kumaraswamy VM, Akeju O, Pierce ET, Cash SS, Brown EN, Purdon PL. The Human Burst Suppression Electoencephalographram of Deep Hypothermia. Clinical Neurophysiology. 2015 Jan 16. pii: S1388-2457(15)00014-0. doi:10.1016/j.clinph.2014.12.022. [Epub ahead of print] PubMed PMID: 25649968; PubMed Central PMCID: PMC4504839.
  61. Cornelissen L, Kim SE, Purdon PL*, Brown EN*, Berde CB*. Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants. Elife. 2015 Jun 23;4. doi: 10.7554/eLife.06513. PubMed PMID: 26102526; PubMed Central PMCID: PMC4502759.*Authors contributed equally
  62. Pavone KJ, Akeju O, Sampson A, Ling K, Purdon PL, Brown EN. Nitrous oxide-induced slow and delta oscillations. Clinical Neurophysiology. 2015 Jun. pii: S1388-2457(15)00629-X. doi: 10.1016/j.clinph.2015.06.001. [Epub ahead of print] PubMed PMID: 26118489.
  63. Chemali JJ, Kenny JD, Olutola O, Taylor NE, Kimchi EY, Purdon PL, Brown EN, Solt K. Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain. British Journal of Anaesthesia. 2015 Jul; 115 Suppl 1:i58-i65. doi: 10.1093/bja/aev112. PubMed PMID: 26174302; PubMed Central PMCID: PMC4501916.
  64. Akeju O, *Pavone KJ, *Thum JA, Firth PG, Westover MB, Puglia M, Shank ES, Brown EN, Purdon PL. Age-dependency of sevoflurane-induced electroencephalogram dynamics in children. British Journal of Anaesthesia. 2015 Jul; 115 Suppl 1:i66-i76. doi: 10. 1093/bja/aev114. PubMed PMID: 26174303; PubMed Central PMCID: PMC4501917.*Authors contributed equally
  65. Purdon PL, Pavone KJ, Akeju O, Smith AC, Sampson AL, Lee J, Zhou DW, Solt K, Brown EN. The aging brain: An age-dependent analysis of the electroencephalogram during propofol and sevoflurane general anesthesia. British Journal of Anaesthesia. 2015 Jul; 115 Suppl 1:i46-i57. doi: 10.1093/bja/aev213. PubMed PMID: 26174300; PubMed Central PMCID: PMC4501918. (Featured on the cover for the Memory and Awareness under Anesthesia Special Edition)
  66. Westover MB, Kim SE, Ching S, Purdon PL, Brown EN. Robust control of burst suppression for medical coma. Journal of Neural Engineering. 2015 Aug; 12(4):046004. doi: 10. 1088/1741-256004. Epub 2015 May 28. PubMed PMID:26020243; PubMed Central PMCID: PMC4517835.
  67. Flores FJ, Ching S, Hartnack K, Fath AB, Purdon PL, Wilson MA, Brown EN. A PK-PD model of ketamine-induced high-frequency oscillations.J Neural Eng. 2015 Oct;12(5):056006. doi: 10.1088/1741-2560/12/5/056006. Epub 2015 Aug 13. PubMed PMID: 26268223.
  68. An JZ, Jonnalagadda D, Junior VM, Purdon PL, Brown EN, Westover BM. Spatial Variation in Automated Burst Suppression Detection in Pharmacologically Induced Coma. Conf Proc IEEE Eng Med Biol Soc 2015. Aug;2015:7430-3. doi: 10.1109/EMBC.2015.7320109.
  69. Ghassemi M, Amorim E, Pati A, Mark R, Brown EN, Purdon PL, Westover BM. An Enhanced Cerebral Recovery Index for Coma Prognostication Following Cardiac Arrest. Conf Proc IEEE Eng Med Biol Soc 2015. Aug;2015:534-7. doi: 10.1109/EMBC.2015.7318417.
  70. Zhou* DW, Westover* BM, McClain LM, Nagaraj SB, Bajwa EK, Quraishi SA, Akeju O, Cobb JP, Purdon PL. Clustering analysis to identify distinct spectral components of encephalogram burst suppression in critically ill patients. Conf Proc IEEE Eng Med Biol Soc 2015. Aug;2015:7258-61. doi: 10.1109/EMBC.2015.7320067.
  71. Akeju O, Hamilos AE, Song AH, Pavone KJ, Purdon PL, Brown EN. GABAA circuit level mechanisms are associated with ether-induced unconsciousness. Clinical Neurophysiology. 2016 Jun;127(6):2472-81. doi: 10.1016/j.clinph.2016.02.012. Epub 2016 Feb 27. PubMed PMID: 27178867; PubMed Central PMCID: PMC4869993.
  72. Krishnaswamy P, Bonmassar G, Poulsen C, Pierce ET, Purdon PL, Brown EN.  Reference-free removal of EEG-fMRI ballistocardiogram artifacts with harmonic regression. 2016 Mar;128:398-412. doi: 10.1016/j.neuroimage.2015.06.088. Epub 2015 Jul 5. PubMed PMID: 26151100; PubMed Central PMCID: PMC4761527.
  73. Akeju O, Song AH, Hamilos AE, Pavone KJ, Flores FJ, Brown EN, Purdon PL. Electroencephalogram Signatures of Ketamine-Induced Unconsciousness. Clinical Neurophysiology. 2016 Jun;127(6):2414-22. doi: 10.1016/j.clinph.2016.03.005. Epub 2016 Mar 16. PubMed PMID: 27178861; PubMed Central PMCID: PMC4871620
  74. Akeju O, Kim SE, Vazquez R, Rhee J, Pavone KJ, Hobbs LE, Purdon PL, Brown EN. Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations. PLoS One. 2016 Oct 6;11(10):e0163431. doi: 10.1371/journal.pone.0163431. eCollection 2016. PMID: 27711165
  75. Nagaraj SB, Ramaswamy SM, Biswal S, Boyle EJ, Zhou DW, Mcclain LM, Rosenthal ES, Purdon PL, Westover MB. Heart rate variability as a biomarker for sedation depth estimation in ICU patients. Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:6397-6400. doi: 10.1109/EMBC.2016.7592192. PMID: 28269712
  76. Nagaraj SB, Biswal S, Boyle EJ, Zhou DW, McClain LM, Bajwa EK, Quraishi SA, Akeju O, Barbieri R, Purdon PL, Westover MB. Patient-Specific Classification of ICU Sedation Levels From Heart Rate Variability. Crit Care Med. 2017 Jul;45(7):e683-e690. doi: 10.1097/CCM.0000000000002364. PMID: 28441231
  77. Pavone KJ, Su L, Gao L, Eromo E, Vazquez R, Rhee J, Hobbs LE, Ibala R, Demircioglu G, Purdon PL, Brown EN, Akeju O. Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power. Front Syst Neurosci. 2017 May 30;11:38. doi: 10.3389/fnsys.2017.00038. eCollection 2017. PMID:28611601
  78. Flores FJ, Hartnack KE, Fath AB, Kim S, Wilson MA, *Brown EN, *Purdon PL. Thalamocortical synchronization during induction and emergence from propofol-induced unconsciousness. Proc Natl Acad Sci U S A 2017 Aug 8;114(32):E6660-E6668. doi: 10.1073/pnas.1700148114. Epub 2017 Jul 25. PMID: 28743752
  79. *Authors contributed equally
  80. Stokes PA, Purdon PL. A Study of Problems Encountered in Granger Causality Analysis from a Neuroscience Perspective. Proc Natl Acad Sci U S A 2017 Aug 22. 114(34):E7063-E7072. doi: 10.1073/pnas.1704663114. Epub 2017 Aug 4.
  81. Pirondini E, Babadi B, Obregon-Henao G, Lamus C, Malik WQ, Hamalainen MS, Purdon PL. Computationally-efficient algorithms for sparse, dynamic solutions to the EEG source localization problem. IEEE Trans Biomed Eng. ePub 2017 Sep 14. doi: 10.1109/TBME.2017.2739824.2018 Jun;65(6):1359-1372.
  82. An J, Purdon PL, Solt K, Sims NM, Brown EN, Westover MB. Design, implementation, and evaluation of a physiological closed-loop control device for medically-induced coma. Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:4313-4316. doi: 10.1109/EMBC.2017.8037810.
  83. Soplata AE, McCarthy MM, Sherfey J, Lee S, Purdon PL, Brown EN, Kopell N. Thalamocortical control of propofol phase-amplitude coupling. PLoS Computational Biology 2017 Dec 11;13(12):e1005879.
  84. Krishnaswamy P, Obregon-Henao G, Ahveninen J, Kahn S, Babadi B, Iglesias JE, *Hamalainen MS, *Purdon PL. Sparsity Enables Estimation of both Subcortical and Cortical Activity from MEG and EEG. Proc Natl Acad Sci U S A 2017 Nov 28;114(48):E10465-E10474. doi: 10.1073/pnas.1705414114. Epub 2017 Nov 14. *Authors contributed equally
  85. Cornelissen L, Kim SE, Lee JM, Brown EN, Purdon PL, Berde CB. Electroencephalographic markers of brain development during sevoflurane anaesthesia in children up to 3 years old. Br J Anaesth. 2018 Jun;120(6):1274-1286. doi: 10.1016/j.bja.2018.01.037. Epub 2018 Apr 5.
  86. Walsh EC, Lee JM, Terzakis K, Zhou DW, Burns S, Buie TM, Firth PG, Shank ES, Houle TT, Brown EN, Purdon PL. Age-Dependent Changes in the Propofol-Induced Electroencephalogram in Children With Autism Spectrum Disorder. Front Syst Neurosci. 2018 Jun 22;12:23. doi: 10.3389/fnsys.2018.00023. eCollection 2018.
  87. Lewis LD, Piantoni G, Peterfreund RA, Eskandar EN, Harrell PG, Akeju O, Aglio LS, Cash SS, Brown EN, Mukamel EA, Purdon PL. A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans. Elife. 2018 Aug 10;7. pii: e33250. doi: 10.7554/eLife.33250.
  88. Sun H, Nagaraj SB, Akeju O, Purdon PL, Westover BM. Brain Monitoring of Sedation in the Intensive Care Unit Using a Recurrent Neural Network. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:1-4. doi: 10.1109/EMBC.2018.8513185. PMID: 30440304; PMCID: PMC6775766.
  89. Beck AM, Stephen EP, Purdon PL. State Space Oscillator Models for Neural Data Analysis.  Conf Proc IEEE Eng Med Biol Soc  Jul;2018:4740-4743. doi: 10.1109/EMBC.2018.8513215.
  90. Lewis LD, Piantoni G, Peterfreund RA, Eskandar EN, Harrell PG, Akeju O, Aglio LS, Cash SS, Brown EN, Mukamel EA, Purdon PL. A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans. Elife. 2018 Aug 10;7. pii: e33250. doi: 10.7554/eLife.33250.
  91. An J, Jonnalagadda D, Moura V Junior, Purdon PL, Brown EN, Westover MB. Variability in pharmacologically-induced coma for treatment of refractory status epilepticus. PLoS One. 2018 Oct 31;13(10):e0205789. doi: 10.1371/journal.pone.0205789. eCollection 2018.
  92. Nagaraj SB, McClain LM, Boyle EJ, Zhou DW, Ramaswamy SM, Biswal S, Akeju O, Purdon PL, Westover MB. Electroencephalogram Based Detection of Deep Sedation in ICU Patients Using Atomic Decomposition. IEEE Trans Biomed Eng. 2018 Dec;65(12):2684-2691. doi: 10.1109/TBME.2018.2813265. Epub 2018 Mar 7.
  93. Liu F, Stephen EP, Prerau MJ, Purdon PL. Sparse Multi-task Inverse Covariance Estimation for Connectivity Analysis in EEG Source Space. Int IEEE EMBS Conf Neural Eng. 2019 Mar;2019:299-302. doi: 10.1109/NER.2019.8717043. Epub 2019 May 20.
  94. Shao YR, Kahali P, Houle TT, Deng H, Colvin C, Dickerson BC, Brown EN, Purdon PL. Low Frontal Alpha Power Is Associated With the Propensity for Burst Suppression: An Electroencephalogram Phenotype for a “Vulnerable Brain”. Anesth Analg. 2020 May 14. doi: 10.1213/ANE.0000000000004781. Epub ahead of print. PMID: 32427658
  95. Subramanian S, Barbieri R, Purdon PL, Brown EN. Detecting Loss and Regain of Consciousness during Propofol Anesthesia using Multimodal Indices of Autonomic State. Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:824-827. doi: 10.1109/EMBC44109.2020.9175366. PMID: 33018112
  96. Liu F, Wang L, Lou Y, Li RC, Purdon PL. Probabilistic Structure Learning for EEG/MEG Source Imaging With Hierarchical Graph Priors. IEEE Trans Med Imaging. 2021 Jan;40(1):321-334. doi: 10.1109/TMI.2020.3025608. Epub 2020 Dec 29. PMID: 32956052
  97. He M, Liu F, Nummenmaa A, Hämäläinen M, Dickerson BC, Purdon PL. Age-Related EEG Power Reductions Cannot Be Explained by Changes of the Conductivity Distribution in the Head Due to Brain Atrophy. Front Aging Neurosci. 2021 Feb 18;13:632310. doi: 10.3389/fnagi.2021.632310. PMID: 33679380; PMCID: PMC7929986
  98. Abel JH, Badgeley MA, Baum TE, Chakravarty S, Purdon PL, Brown EN. Constructing a control-ready model of EEG signal during general anesthesia in humans. Proc IFAC World Congress. 2020;53(2):15870-15876. doi: 10.1016/j.ifacol.2020.12.243. Epub 2021 Apr 14. PMID: 34184002; PMCID: PMC8236287.
  99. Abel JH, Badgeley MA, Meschede-Krasa B, Schamberg G, Garwood IC, Lecamwasam K, Chakravarty S, Zhou DW, Keating M, Purdon PL, Brown EN. Machine learning of EEG spectra classifies unconsciousness during GABAergic anesthesia. PLoS One. 2021 May 6;16(5):e0246165. doi: 10.1371/journal.pone.0246165. PMID: 33956800; PMCID: PMC8101756
  100. Subramanian S, Purdon PL, Barbieri R, Brown EN. Elementary integrate-and-fire process underlies pulse amplitudes in Electrodermal activity. PLoS Comput Biol. 2021 Jul 7;17(7):e1009099. doi: 10.1371/journal.pcbi.1009099. PMID: 34232965.
  101. Soulat H, Stephen EP, Beck AM, Purdon PL. State Space Methods for Phase Amplitude Coupling Analysis. BIORXIV/2019/772145 (in review). 

Other Peer-reviewed Publications

  1. Brown EN, Purdon PL, Van Dort CJ. General anesthesia and altered states of arousal: A systems neuroscience analysis. Rev. Neurosci. 2011;34:601–28. PMID:21513454 PMCID: PMC3390788
  1. Brown EN, Purdon PL. The aging brain and anesthesia. Curr Opin Anesthesiol. 2013 Aug;26(4):414-9. doi: 10.1097/ACO.0b013e328362d183. PMID:23820102
  1. Purdon PL, Sampson A, Pavone KJ, Brown EN. Clinical Electroencephalography for Anesthesiologists: Part I: Background and Basic Signatures. Anesthesiology. 2015 Oct;123(4):937-60. doi: 10.1097/ALN.0000000000000841. PubMed PMID: 26275092; PubMed Central PMCID: PMC4573341. (Featured Article in “This Month in: Anesthesiology” and on mobile web “Featured Articles”)
  1. Purdon PL, Zhou DW, Akeju O, Brown EN. In Reply. Anesthesiology. Anesthesiology. 2015 Sep;123(3):725-8. doi: 10.1097/ALN.0000000000000794 (Originally Titled “The electroencephalogram: a ‘missing piece’ in personalized anesthesia care.”)
  1. Prerau MJ, Brown RE*, Bianchi MT, Ellenbogen JM, Purdon PL. Sleep Neurophysiologic Dynamics Through the Lens of Multitaper Spectral Analysis. Physiology (Bethesda). 2017 Jan;32(1):60-92.
  1. Purdon PL. Brain Oscillations During Child Development: Insights from the Neurophysiology of Anesthetic Drugs. Ernst Strungmann Forum: Manifestations and Mechanisms of Dynamic Brain Coordination over Development. March 5–10, 2017.
  1. Brown EN, Purdon PL, Akeju O, An J. Using EEG markers to make inferences about anaesthetic-induced altered states of arousal. Br J Anaesth. 2018 Jul;121(1):325-327. doi: 10.1016/j.bja.2017.12.034. Epub 2018 Mar 14.
  1. Stokes PA, Purdon PL. Reply to Barnett et al.: Regarding interpretation of Granger causality analyses. Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6678-E6679. doi: 10.1073/pnas.1807099115. Epub 2018 Jul 10.
  1. Chan MTV, Hedrick TL, Egan TD, García PS, Koch S, Purdon PL, Ramsay MA, Miller TE, McEvoy MD, Gan TJ; Perioperative Quality Initiative (POQI) 6 Workgroup. American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on the Role of Neuromonitoring in Perioperative Outcomes: Electroencephalography. Anesth Analg. 2020 May;130(5):1278-1291. doi: 10.1213/ANE.0000000000004502. PMID: 31764163.
  1. Mahanna-Gabrielli E, Schenning K, Eriksson L, Wright C, Evered L , Scott D, Wang NY, Brown C, Oh E, Inouye S, Purdon PL, Berger M, Browndyke J, Deiner S. White Paper, State of the Clinical Science of Perioperative Brain Health, A Report From the American Society of Anesthesiology Brain Health Initiative Summit 2018. Br J Anaesth. 2019 Oct;123(4):464-478. doi: 10.1016/j.bja.2019.07.004. Epub 2019 Aug 19.PMID: 31439308
  1. Brandt SP, Walsh EC, Cornelissen L, Lee JM, Berde C, Shank ES, Purdon PL. Case Studies Using the Electroencephalogram to Monitor Anesthesia-Induced Brain States in Children. Anesth Analg. 2020 Oct;131(4):1043-1056. doi: 10.1213/ANE.0000000000004817. PMID: 32925322; PMCID: PMC7467151